NSAID's [such as Ibuprofin] are among the most frequently prescribed drugs in women, but our knowledge of possible negative effects on the outcome of pregnancies is limited.
The use of these drugs in the third trimester is contra-indicated due to well-described adverse events.
Recent epidemiological studies have raised concern about a possible increased risk of early spontaneous abortion and cardiac malformations associated with use of NSAIDs in early pregnancy. However, other studies have been unable to confirm these findings.
As long as these uncertainties exist, use of NSAIDs should be discouraged throughout pregnancy.
Ugeskr Laeger. 2006 Oct 23;168(43):3709-11.
